The CH382L uses memory-mapped I/O, not traditional ISA-style I/O ports. Some legacy software (like old DOS-based parallel programmers) assumes direct I/O port access (0x378, 0x278). You may need , GiveIO , or InpOut32 to grant access. However, modern Windows 10 security blocks this. Consider running such software in a Windows XP virtual machine with PCIe passthrough.
If using the .EXE file, simply run it as an administrator to automatically register the driver. wch ch382l driver windows 10
Windows will identify the port and finish the setup. Key Features of the CH382L Chip The CH382L uses memory-mapped I/O, not traditional ISA-style