Juq-063 __full__

: The pulp is refined to make the fibers smaller and more flexible. This is done by passing the pulp through a series of rollers.

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Beyond the Frame: Deconstructing Narrative, Aesthetic, and Subtext in JUQ-063 : The pulp is refined to make the

| Cohort | Design | Doses (mg) | N | Primary endpoints | Key outcomes | |--------|--------|------------|---|-------------------|--------------| | | Randomised, double‑blind, placebo‑controlled, single ascending dose (fasted). | 5, 10, 30, 60, 120 | 48 | Safety, PK, KOR occupancy (PET) | Well‑tolerated; linear PK (C max ∝ dose); 30 mg achieved 80 % occupancy at 2 h; no QTc effect. | | MAD | 10‑day repeated dosing (q.d.) | 10, 30, 60 | 36 | Safety, steady‑state PK, PD (cortisol, mood VAS). | Steady‑state reached by day 4; mild GI upset in 12 % (all resolved); cortisol blunted stress‑induced rise by 18 % at 30 mg. | | Food‑effect | 30 mg PO fasted vs fed ( | Steady‑state reached by day 4; mild GI