David Bioinformatics Resources

In 2016, the DAVID team released a major update. They introduced the , a massive structured collection of gene-annotation associations. More importantly, they opened up programmatic access via APIs.

: Allows users to convert gene lists between species (e.g., mouse to human) to leverage better-annotated model organisms for analysis. david bioinformatics resources

So, Huang, then a postdoctoral fellow at the National Institute of Allergy and Infectious Diseases (NIAID), did what any frustrated scientist would do—he built a tool to solve his own problem. That tool would eventually become . In 2016, the DAVID team released a major update

| Use case | DAVID | Alternative(s) | |---|---:|---| | Quick web-based enrichment with clustering | Good | Enrichr, WebGestalt | | Programmatic/large-scale automated pipelines | Limited (older SOAP API) | clusterProfiler, g:Profiler | | Up-to-date pathway annotations | Moderate (may lag) | Reactome, g:Profiler | | Extensive visualization & publication-ready plots | Basic | clusterProfiler, Enrichr, Cytoscape plugins | : Allows users to convert gene lists between species (e

A plant geneticist identifies 1,000 genes differentially expressed during drought stress. DAVID (supporting Arabidopsis , Rice , Maize ) shows enrichment for "Response to abscisic acid" and "Stomatal closure."